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Taken together, our findings suggest that EZH2 inhibitors could be a good therapeutic option for HCC, and induction of MT genes was associated with the anti-HCC activity of EZH2 inhibitors.The inhibition of β-catenin/LEF-1 signaling is an emerging strategy in cancer therapy.Results In both the mi RNA microarray and real-time PCR, mi R-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P Accumulated evidence demonstrated that long non-coding RNAs (lnc RNAs) play a pivotal role in tumorigenesis.However, it is still largely unknown how these lnc RNAs were regulated by small nc RNAs, such as micro RNAs (mi RNAs), at the post-transcriptional level.Our study suggests that TAT-NLS-BLBD-6 is a promising drug candidate for the development of effective therapeutics specific for Wnt/β-catenin signaling inhibition.Background After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery.Consistent with this notion, a significant negative correlation between these mi RNAs and HOTTIP exists in HCC tissue specimens.Interestingly, the dysregulation of the three nc RNAs was associated with overall survival of HCC patients.

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TAT-NLS-BLBD-6 commonly down-regulated 27 candidate genes in MCF-7 and MDA-MB-231 cells, which are concurrent with Wnt downstream target genes in human breast cancer.In vivo mouse xenograft model also support the tumor suppressor role of both mi RNAs.Besides the known targets (multiple 5’ end HOX A genes, i.e.These results elucidate that the mi R-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis.Our data in clinical HCC samples highlight mi R-192, mi R-204 and HOTTIP with prognostic and potentially therapeutic Overexpression of Human epididymis protein 4 (HE4) related with a role in ovarian cancer tumorigenesis while little is known about the molecular mechanism alteration by HE4 up regulation.

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